3-CHLORO-2,6-DIFLUOROBENZOIC ACID

3-CHLORO-2,6-DIFLUOROBENZOIC ACID - Names and Identifiers

Name	3-Chloro-2,6-Difluorobenzoic Acid
Synonyms	RARECHEM AL BE 0491 3-CHLORO-2,6-DIFLUOROBENZOIC ACID 3-Chloro-2,6-Difluorobenzoic Acid Benzoic acid, 3-chloro-2,6-difluoro-
CAS	225104-76-7
EINECS	630-263-2

3-CHLORO-2,6-DIFLUOROBENZOIC ACID - Physico-chemical Properties

Molecular Formula	C7H3ClF2O2
Molar Mass	192.55
Density	1.573
Melting Point	126-128°C
Boling Point	265℃
Flash Point	114℃
pKa	1.97±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
MDL	MFCD01631322

3-CHLORO-2,6-DIFLUOROBENZOIC ACID - Risk and Safety

Risk Codes	R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R22 - Harmful if swallowed
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
Hazard Class	IRRITANT

3-CHLORO-2,6-DIFLUOROBENZOIC ACID - Reference Information

Use

3-chloro-2, 6-difluorobenzoic acid is a pharmaceutical intermediate of quinolone and pyrazole antibacterial agents.

preparation

2, 4-difluoroaniline (2) is used as the raw material to obtain 2 by diazotization, 4-difluorochlorobenzene, 3-chloro-2, 6-difluorobromobenzene was obtained by bromination reaction with NBS, and the target compound 3-chloro-2 was obtained after acidification by Grignard reaction, 6-difluorobenzoic acid. Compared with the above four methods, this method adopts mild reaction conditions, has abundant raw materials, is simple to operate, and is more suitable for industrial production.

Last Update：2024-04-10 22:29:15